Experimental drug could help ease menopause symptoms, researchers say

A new drug could potentially alleviate two of the most problematic problems Effects of menopause.

The drug, called Pool 7 Compound 3 (P7C3), could help reduce bone loss Weight gain in postmenopausal women, according to researchers at the University of Central Florida (UCF).

The drug is also being studied as a therapy for Alzheimer’s, Parkinson’s and other neurological diseases.


“Current drugs administered to prevent postmenopausal bone loss target specific cells or proteins,” lead researcher Melanie Coathup, a UCF biomedical engineer, told Fox News Digital.

“They therefore tend to cause problems after long-term use or through secondary complications in other, unrelated tissues in the body.”

Woman's neck pain

According to the study’s lead researcher, many women live with medical challenges associated with menopause that “cause them embarrassment” about maintaining and maintaining their health. (iStock)

The results of the study were published in the journal Advanced Science.

To date, there is no safe long-term treatment for bone loss in women, the researchers claimed in the UCF press release.

Many women suffer from the medical challenges associated with menopause, leaving them at a loss and unsure of how to maintain and maintain it sound Healthsaid Coatup.


The researcher said she is often “inundated” with questions. elderly lady who are afraid of breaking a bone and are “desperately looking for help”.

“There is a significant gap in medical support for postmenopausal women – and P7C3 may provide hope that a new alternative is on the horizon,” she said.

Woman at the doctor

The new drug has been shown to prevent bone loss and maintain healthy bone volume after menopause. (iStock)

In studies on mice, the new drug was shown to prevent bone loss and maintain healthy bone volume.

“The bone remained strong – it was harder to break with a machine – even though our models had little to no estrogen,” Coathup said in the press release.

What is Osteoporosis?

Osteoporosis is a disease that causes weak, brittle bones. It is typically caused by overactive cells absorbing too much bone.

Symptoms may appear in the later stages of the disease Back painstooped posture and broken bones, according to the Mayo Clinic.


According to the National Institutes of Health (NIH), more than 200 million people suffer from osteoporosis, including over 70% of people over the age of 80.

Women are more vulnerable than men.

P7C3 inhibits the activity of bone-absorbing cells.

“There is a significant gap in medical support for postmenopausal women.”

The drug has also been found to reduce inflammation and form new, healthy bone tissue.

“Our metabolism declines as we age and plays an important role in almost every tissue in the body,” Coathup told Fox News Digital.

“An important finding is therefore that P7C3 may not only cause fewer unwanted side effects, but may also improve the health of many tissues in addition to bone and fat, possibly including our muscles, memory and cognition.”

Woman lifts weight

Experts recommend that menopausal women build muscle through weight-bearing exercises. (iStock)

The drug has also been found to prevent postmenopausal weight gain by increasing the beneficial bacteria in the body Gut microbiome and stimulate fat metabolism.

“Massive whole-body weight gain is common in postmenopausal osteoporosis and low estrogen levels in both humans and rats,” noted Coathup.

“The finding that P7C3 reduced total fat stores and body weight was highly unexpected,” she also said.

“Promising” initial results

Dr. Kathleen Jordan, chief medical officer at Midi Health in California, was not involved in the study but offered her opinion on what she called a “commendable” study.

“It is exciting that there is urgent research into bone health, particularly in women where the lack of estrogen during menopause makes them particularly vulnerable poor bone health“,” she told Fox News Digital.

To combat bone loss, the FDA approves a vibration belt proven to help postmenopausal women

Osteoporosis can lead to “fragility fractures,” Jordan warned — referring to “fractures that can result from minor impacts in daily life.” [that] are painful and debilitating.”

While P7C3 could pave the way for additional therapies for women, Jordan noted that the drug is still “very early in development and not yet ready for widespread clinical use.”

Osteoporosis split

Strategies to prevent osteoporosis include weight-bearing exercise and a diet high in calcium and vitamin D, experts say. (iStock)

“I look forward to the results of future safety and effectiveness studies,” she added.

Coathup agreed more research is required, but said the early signs were “very positive.”

“I hope our research gives women hope, albeit cautious hope,” she said. “The results were incredible and surprisingly promising.”

What women can do now

UFC researchers also want to study whether the drug can help restore bone mass in women who already have osteoporosis.

Meanwhile, Coathup recommends menopausal women eat a diet high in calcium and vitamin D Talk to your doctors as needed and to build muscle through strenuous exercises such as walking, jogging, dancing or playing tennis.


“Following this advice will help women live healthier lives during menopause and have a greater chance of avoiding bone loss and weight gain,” she said.

Jordan disputed researchers’ claims that there are no effective treatments for bone loss, saying women should have access to currently available solutions.

Osteoporosis, bone disease

Osteoporosis can lead to “fragility fractures,” a doctor warned – “these are fractures that can occur from small impacts in daily life and are painful and debilitating.” (iStock)

“It has long been known that estrogen replacement has a supportive effect Women’s Bone Healthreduce the incidence of osteopenia and osteoporosis and prevent fractures,” she said.

(The US Preventive Services Task Force, or USPSTF, “advises against the use of a combination of estrogen and progestin for the primary prevention of chronic disease in postmenopausal individuals,” according to its website.)


In addition to weight-bearing exercises and a optimized nutritionBone density tests are also important, Jordan said – especially for women with certain risk factors.

These factors include, but are not limited to, the fact that the mother has broken bones or problems with bone health, consumes a lot of alcohol, has diabetes, or regularly takes prednisone or other steroids.

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